Nonglycoside cardiotonic drugs
The drug is a natural hormone. It is synthesized through methylation of noradrenaline and stored in the adrenal chromaffin tissue.
Acute-phase allergic reactions: anaphylactic shock due to the use of drugs or sera or due to contact with allergens; bronchial asthma: for termination of attacks; asystole; cardiac arrest; prolonging the effect of local anesthetics; acute third-degree AV block.
The drug is used subcutaneously, intramuscularly, sometimes as an intravenous injection or drip.
Anaphylactic shock: administer the drug intravenously slowly at a dose of 0.5 mL, in diluted form (a single dose is diluted in 20 mL of 40% glucose solution). Afterward, if necessary, continue to administer by intravenous drip at 1 µg/min; for this, 1 mL of adrenaline solution is diluted in 400 mL of 0.9% sodium chloride solution or 5% glucose solution. If the patient's condition allows, intramuscular or subcutaneous injection of 0.3–0.5 mL of the drug in diluted or nondiluted form is more appropriate.
Bronchial asthma: 0.3–0.5 mL of the drug is injected subcutaneously in diluted or nondiluted form. If repeat administration is necessary, the same dose may be used every 20 minutes (up to 3 times). It is also possible to inject 0.3–0.5 mL of the drug intravenously in diluted form (a single dose is diluted in 20 mL of 40% glucose solution).
As a vasoconstrictor: the drug is administered by intravenous drip at 1 µg/min (may be increased up to 2–10 µg/min).
Asystole: the drug is injected into the heart at a dose of 0.5 mL in diluted form (a single dose is diluted in 10 mL of 0.9% sodium chloride solution).
Resuscitation (cardiac arrest, acute third-degree AV block): the drug is injected intravenously slowly by 1 mL every 3–5 minutes, in diluted form.
Prolonging the effects of local anesthetics: the drug is administered in a concentration of 1:50,000–1:100,000. The dosing depends on the type of the anesthetic.