Medications used in liver disease, lipotropic substances
The active substance—arginine glutamate—plays a crucial role in the biochemical processes of neutralizing and excreting out of the body a highly toxic product of nitrogen metabolism—ammonia. The drug exerts its hypoammonemic effects through activating ammonia neutralization in the ornithine cycle of urea synthesis by binding ammonia to nontoxic glutamine as well as by increasing ammonia excretion from the central nervous system and the body.
– Hepatic encephalopathy, precoma and coma with hyperammonemia
– Moderate to severe acute alcoholic intoxication, including alcoholic encephalopathy and coma; postintoxication disorders caused by alcohol consumption
– Complications in the third semester of pregnancy: late toxemia, including its severe forms—preeclampsia and eclampsia, fetoplacental failure, chronic hepatobiliary system pathologies in pregnancy, including conditions with hyperammonemia
– In complex treatment of acute and chronic hepatitis of various etiology, including due to poisoning with hepatotropic toxins (death cap mushroom, chemicals, and pharmaceuticals), liver cirrhosis, leptospirosis, including conditions with hyperammonemia
In adults, the drug is used intravenously. Before administration, the ampoules should be examined for the presence of particulate matter or changes in the solution color.
Hepatitis, hyperammonemia. The drug should be administered by intravenous drip, 50 mL (2 g) per 150–250 mL of 0.9% sodium chloride solution twice daily at 60–70 drops per minute. In severe cases, the daily dose of the drug is increased up to 150–200 mL (6–8 g). The course of treatment is 5 to 10 days. The maximum daily dose is 200 mL (8 g).
Alcoholic intoxication. 20 mL (0.8 g) of the drug is administered by intravenous drip in 150–250 mL of 0.9% sodium chloride solution twice daily at 60–70 drops per minute for 2–3 days, then the dose is decreased to 10 mL (0.4 g) twice daily for 10 days. In severe cases (alcoholic coma), the daily dose is increased up to 50 mL (2 g) twice daily.
Pathology of pregnancy (third trimester). The drug is administered by 50 mL (2 g) 1–2 times per day. The course of treatment is 5 to 7 days. The maximum daily dose is 100 mL (4 g).
The efficacy and safety of the drug in children have not been studied.