Medications used in liver disease, lipotropic substances. Arginine glutamate
Argitec is combination of arginine and glutamic acid that play a crucial role in the biochemical processes of neutralizing and excreting out of the body a highly toxic product of nitrogen metabolism—ammonia. The drug exerts its hypoammonemic effects through activating ammonia neutralization in the ornithine cycle of urea synthesis by binding ammonia to nontoxic glutamine as well as by increasing ammonia excretion from the central nervous system and the body.
In complex treatment of acute and chronic hepatitis of various etiology, including due to poisoning with hepatotropic toxins (death cap mushroom, chemicals, and pharmaceuticals), liver cirrhosis, leptospirosis, hepatic encephalopathy, precoma and coma that are accompanied by nitrogen metabolism disorders and hyperammonemia. Moderate to severe acute alcoholic intoxication, including alcoholic encephalopathy and coma, and also as part of complex treatment of postintoxication disorders after acute alcohol intoxication.
The drug is administered in adults intravenously.
The drug is administered by intravenous drip, 1 vial (2 g) twice daily at 60–70 drops per minute.
In severe cases, the daily dose is increased up to 3–4 vials (corresponding to 6–8 g), divided in 2 doses.
Alcoholic intoxication. The drug should be administered by intravenous drip, 100 mL twice daily
(0.8 g) at 60–70 drops per minute.
In severe cases (alcoholic coma), the daily dose is increased up to 1 vial (2 g) twice daily.
The maximum daily dose is 8 g. The course of treatment is 5 to 10 days.