Systemic antimicrobial agents. Tetracyclines. Doxycyclinе
Doxycyclinе is a semisynthetic antibiotic that belongs to broad-spectrum tetracyclines. It has bacteriostatic activity due to inhibition of protein synthesis in the pathogen by blocking bonds between the aminoacyl-tRNA and «messenger RNA (mRNA) – ribosome» complex.
Treatment of infections caused by susceptible strains of gram-positive and gram-negative bacteria as well as some other microorganisms.
Treatment of infections caused by microorganisms susceptible to tetracyclines.
The drug is used orally during or after a meal (can be taken with milk or drinking yogurt).
Adults and children with a body weight of over 45 kg.
On the first day of treatment of acute infections, the daily dose is 200 mg once or 100 mg twice with a 12-hour interval, for the following days the dose is 100 mg. For the treatment of severe infections, the drug should be used at 200 mg daily during the entire period of treatment.
The duration of treatment is determined by a physician on an individual basis; the treatment is continued for at least 24–48 hours after the disappearance of symptoms and normalization of body temperature.
Children younger than 12 with a body weight of below 45 kg.
On the first day of treatment, the daily dose is 4.4 mg/kg of body weight (as 1 or 2 doses), in the following days the dose is 2.2 mg/kg of body weight (as 1 or 2 doses). For the treatment of severe infections, the dose of 4.4 mg/kg of body weight can be administered for the entire period of treatment.