Systemic drugs for obstructive respiratory diseases. Xanthines. Theophylline
Theophylline is a bronchodilator, antispasmodic agent. The bronchodilator action mechanism is due to the ability of theophylline to block adenosine receptors, non-selectively inhibit the phosphodiesterase enzyme and thereby increase the concentration of 3',5'-cyclic AMP (cAMP) in tissues, inhibit the calcium ion transport through the slow cell membrane channels and reduce its exit from the intracellular depot. Bronchial obstructive syndrome in bronchial asthma, bronchitis, pulmonary emphysema, respiratory center disorders (paroxysmal nocturnal dyspnea), pulmonary heart disease.
Bronchial obstructive syndrome in bronchial asthma, bronchitis, pulmonary emphysema, respiratory center disorders (paroxysmal nocturnal dyspnea), pulmonary heart disease.
The drug should be administered intravenously. The dose of the drug should be selected on an individual basis, considering the possibility of different excretion rate.
If the patient takes theophylline orally, the theophylline dose for parenteral administration should be decreased.
The patient should be lying down when the drug is administered; the physician controls the blood pressure, heart rate, respiratory rate and general condition of the patient.