Drugs for the treatment of peptic ulcers and gastroesophageal reflux disease. Н2 receptors antagonists
Famotidinе blocks H2 histamine receptors in the stomach wall, thus decreasing the secretion of gastric juice. Famotidinе reduces both the concentration and amount of gastric juice, and, accordingly, the amount of pepsin.
Benign gastric ulcer.
Duodenal ulcers (treatment and prevention of relapses).
Hypersecretory conditions, such as Zollinger – Ellison syndrome.
Treatment of gastroesophageal reflux disease (reflux esophagitis).
Prevention of the development of symptoms and erosions or ulcer formation associated with gastroesophageal reflux disease.
Famotidinе is most effective at night before sleep. When famotidinе is taken twice a day, the first dose should be taken in the morning and the second should be taken at night before sleep.
The tablet is swallowed whole with a glass of water without chewing. Famotidinе is used regardless of food intake.
Gastric and duodenal ulcers (benign).
2 20 mg tablets at night before sleep for 4–8 weeks.
Prevention of duodenal ulcer recurrence.
In order to prevent recurrences, a maintenance dose of 1 20 mg tablet once before sleep for 1–4 weeks is prescribed after achieving a therapeutic effect.
Gastroesophageal reflux disease (reflux esophagitis).
1 or 2 20 mg tablets (depending on the disease severity) 2 times per day. The treatment lasts for 6–12 weeks.
In gastroesophageal reflux disease associated with erosive esophagitis or ulcers — 40 mg twice per day for 6–12 weeks.
To prevent recurrences of symptoms and erosion or ulceration associated with gastroesophageal reflux disease (maintenance therapy).
20 mg twice per day should be prescribed.
Zollinger – Ellison syndrome.
The dose of the medicine is selected on an individual basis. Patients who have not previously taken antisecretory medicines are prescribed the initial dose of 1 20 mg tablet 4 times per day (every 6 hours). For patients who have previously used other H2 histamine receptor antagonists, a higher initial dose of 40 mg every 6 hours can be prescribed immediately. Subsequently, the dose is adjusted depending on the level of gastric juice secretion and the clinical condition of the patient. Treatment should be continued while clinical symptoms of the disease are observed.