Furosemide is a fast-acting loop diuretic with a relatively strong and short-term diuretic effect. Furosemide blocks the Na+K+2Cl-cotransporter located in the basal cell membranes of the thick segment of the ascending limb of the loop of Henle – thus the effectiveness of the saluretic effect of furosemide depends on whether the medicine reaches the lumina of the tubules in via an anion transport mechanism.
– Oedemas in chronic congestive heart failure (if treatment with diuretics is required).
– Oedemas in nephrotic syndrome (if treatment with diuretics is required).
– Oedemas in chronic renal failure.
– Acute renal failure, including in pregnant women or during childbirth.
– Oedemas in liver diseases (if required to supplement the treatment with aldosterone antagonists).
The dosing regimen is determined by the physician on an individual basis depending on the degree of water-electrolyte imbalance, the glomerular filtration rate, and the severity of the patient's condition. The drug should be taken on an empty stomach.
For adults the maximum total daily dose of Furosemide-Darnitsa should not be more than 1500 mg.