Combination ACE inhibitors. Captopril and diuretics
Captopres-Darnitsa is a combination antihypertensive medicine containing a fixed-dose combination of captopril and hydrochlorothiazide. Captopril is an angiotensin-converting enzyme (ACE) inhibitor.
The medicine is administered orally 1 hour before a meal, since food in the stomach reduces the absorption.
The dose is selected individually by the physician, depending on the disease presentation.
The initial dose is ½ tablet (25 mg captopril and 12.5 mg hydrochlorothiazide) once per day.
Later, the maintenance dose can be increased to 1 tablet (50 mg captopril and 25 mg hydrochlorothiazide) once per day, if required.
The maximum therapeutic effect is achieved 6-8 weeks after the start of treatment. Dose adjustments should be made at 6-week intervals if clinical manifestations do not require a more rapid dose change. If the blood pressure is insufficiently lowered, captopril and hydrochlorothiazide can be included in the treatment regimen as monodrugs. The daily dose of captopril should not exceed 150 mg, that of hydrochlorothiazide — 50 mg.
Patients with impaired renal function.
Since captopril and hydrochlorothiazide are excreted predominantly by the kidneys, the level of the drugs may increase if their function is impaired. A dose reduction is recommended: in creatinine clearance of 30 to 80 ml/min, the initial dose is ½ tablet (25 mg captopril and 12.5 mg hydrochlorothiazide) once per day in the morning.
There are no data on the use of the medicine in children.