Captopres 12,5-Darnitsa is a combination antihypertensive medicine containing a fixed-dose combination of captopril and hydrochlorothiazide. Captopril is an angiotensin-converting enzyme (ACE) inhibitor.
The medicine is administered orally 1 hour before a meal, since food in the stomach reduces medicine absorption.
The dose is selected individually by the physician, depending on the disease presentation.
The initial dose may be ½ tablet (25 mg captopril and 6.25 mg hydrochlorothiazide) once per day.
Later, the maintenance dose can be increased to 1 tablet (50 mg captopril and 12.5 mg hydrochlorothiazide) once per day, if required.
The maximum therapeutic effect is achieved 6-8 weeks after the start of treatment. Dose adjustments should be made at 6-week intervals if clinical manifestations do not require a more rapid dose change. If the blood pressure reduction is insufficient, captopril and hydrochlorothiazide can be included in the treatment regimen as monodrugs. The daily dose of captopril should not exceed 150 mg, that of hydrochlorothiazide — 50 mg.