As an anticonvulsant, the carbamazepine spectrum of activity includes: partial seizures (simple and complex) with and without secondary generalization; generalized tonic-clonic seizures, as well as combinations of these types of seizures. The mechanism of action of carbamazepine is only partially elucidated.
– complex or simple partial seizures (with or without loss of consciousness) with or without secondary generalisation;
– generalised tonic-clonic seizures;
– mixed seizures.
– Carbamazepine can be used either as monotherapy or as part of combination therapy.
– Acute mania; maintenance therapy for bipolar affective disorders to prevent relapses or to attenuate the clinical manifestations of relapses.
– Alcohol withdrawal syndrome.
– Idiopathic trigeminal neuralgia and trigeminal neuralgia in multiple sclerosis (typical and atypical).
– Idiopathic neuralgia of the glossopharyngeal nerve.
Carbamazepine is intended for oral use; the daily dose of the drug should be divided into two or three doses. The drug can be taken during, after, or between meals with a small amount of liquid, e.g. a glass of water.
Patients who are potential carriers of the HLA-A*3101 allele by ethic origin should be screened for it prior to treatment, as it may cause severe adverse reactions such as skin reactions.
Adults: The recommended initial dose of the drug is 100-200 mg 1-2 times per day. The dose is then slowly increased until the optimum effect is achieved; the daily dose is commonly 800-1,200 mg. Some patients may require a dose of up to 1,600 mg or even 2,000 mg per day.