Nonsteroidal anti-inflammatory and anti-rheumatic drugs. Acetic acid derivatives and related compounds
Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID), a cyclooxygenase (COX) inhibitor, a pyrrolizine carboxylic acid derivative with a pronounced analgesic effect. Due to the dosage form features, the duration of analgesic action is 10-12 hours.
Moderate and severe postoperative pain short-time relief.
Recommended for use in an inpatient setting. After intramuscular injection, the analgesic effect is observed after about 30 minutes and the maximum analgesia occurs in 1-2 hours. In general, the average duration of analgesia is 8-12 hours. The dose should be adjusted depending on the pain severity and the patient's response to treatment.
Continuous intramuscular administration of multiple daily doses of ketorolac should not exceed 2 days since prolonged use increases the risk of adverse reactions. The experience of long-term use is limited since the vast majority of patients were switched to oral drug administration, or after a period of intramuscular injection patients no longer required analgesic therapy.
The probability of adverse effects can be minimised by using the lowest effective dose for the shortest period of time required to control the symptoms. The drug is not intended for epidural or intraspinal administration.
The drug is contraindicated in children under 16 years.