Respiratory analeptics. Nikethamide
Mixed-action analeptic. The mechanism of action comprises two components: central and peripheral.
– Collapse and asphyxia (including neonatal asphyxia);
– shock in the intraoperative and postoperative period;
– acute and chronic circulatory disorders;
– decrease in vascular tone and respiratory depression in patients with infectious diseases and during recovery;
– poisoning with hypnotics and analgesics (as part of complex therapy).
Single and daily doses, frequency of administration are selected individually by the physician depending on the indications and age of the patient.
The drug is administered subcutaneously, intramuscularly, intravenously. Adults and children over 14 should be prescribed 1–2 ml 1–3 times per day.
For intravenous administration, dilute a single dose with 10 ml of 0.9% sodium chloride solution; administer over 1-3 minutes.
Higher doses for adults subcutaneously: 2 ml - single dose, 6 ml - daily dose. The highest single dose subcutaneously and intravenously for poisoning in adults - 5 ml.
Children are prescribed the following single doses subcutaneously depending on age:
under 1 year — 0.1 ml;
1–4 years— 0.15–0.25 ml;
5–6 years — 0.3 ml;
7–9 years — 0.5 ml;
10–14 years— 0.75 ml.
Administer 1-3 times per day.
The drug is authorised for use in paediatric practice at the recommended doses for the age. Contraindicated in hyperthermia.