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Systemic antibacterial agents

Levomicetin (chloramphenicol) is a broad-spectrum bacteriostatic antibiotic. Its action is related to the disruption of protein synthesis in a microbial cell during the stage of amino acid transfer to ribosomes by tRNA.

Infectious diseases caused by susceptible microorganisms: typhoid fever, paratyphoid, yersiniosis, brucellosis, shigellosis, salmonellosis, tularemia, rickettsiosis, chlamydiosis, purulent peritonitis, bacterial meningitis, bile duct infections.

The drug is indicated when other antimicrobial agents are ineffective due to the possibility of pronounced adverse effects.

Take orally 30 minutes before meals; in case of nausea, vomiting — 1 hour after meals.

The dosage regimen should be selected individually depending on the disease severity and the patient's condition.

In adults use 250–500 mg 3–4 times per day. The daily dose is 2000 mg. In particularly severe cases, the drug can be administered orally at a dose of up to 4000 mg (maximum daily dose for adults) per day under the strict control of the blood, as well as liver and kidney function. The daily dose should be divided into 3–4 doses.

In children from 3 to 8 years of age use a single dose of 125 mg, for children of 8 years of age and over — 250 mg. The dose frequency is 3–4 times per day.

The course of treatment is 7 to 10 days. If indicated, in case of good tolerability and absence of changes in the peripheral blood composition, it is possible to extend the treatment course to 2 weeks.


For use in children 3 years of age and over.

The drug is prescribed for the treatment of children 3 years of age and over with extreme caution and only in the absence of alternative therapy.

Specialized edition for medical institutions and doctors.