Drugs affecting the digestive system and metabolic processes. Thioctic acid
α-lipoic acid is a vitamin-like substance of endogenous origin that functions as a coenzyme in the oxidative decarboxylation of α-keto acids. Diabetes-induced hyperglycemia leads to the accumulation of so-called «advanced glycation end products».
Symptomatic treatment of diabetic sensorimotor polyneuropathy.
The basis for treating diabetic polyneuropathy is optimal diabetic control. The doses and duration of treatment are selected individually.
In the presence of symptoms of diabetic sensorimotor polyneuropathy the recommended daily dose for adults is 600 mg of thioctic acid per day intravenously.
During the initial treatment period, the prepared solution should be administered intravenously for 2–4 weeks.
Only 0.9% sodium chloride solution should be used for the preparation of the infusion solution.
Lipoica is administered as an intravenous drip for 30 minutes, the contents of the ampoule are preliminary diluted in 250 ml of 0.9% sodium chloride solution.
The infusion solution should be protected from light (e.g. using aluminium foil). The infusion solution protected from light is usable for approximately 6 hours.
It is recommended to continue the therapy with α-lipoic acid in oral dosage forms at a dose of 600 mg per day.