Peristaltic stimulants (propulsants)
Metoclopramide is a central dopamine antagonist that also exhibits peripheral cholinergic activity. There are two main effects: antiemetic and acceleration of gastric emptying and passage through the small intestine.
Metoclopramide is indicated for adults to prevent nausea and vomiting caused by radiotherapy, delayed nausea and vomiting caused by chemotherapy, as well as symptomatic treatment of nausea and vomiting, including those associated with acute migraine (in combination with oral analgesics for improving their absorption).
Metoclopramide should only be used in children as a second-line medicine to prevent delayed nausea and vomiting caused by chemotherapy.
For oral administration before meals, without chewing, with a sufficient amount of liquid.
In order to minimise the risks of adverse reactions from the nervous system and other adverse reactions, metoclopramide should only be used for short-term treatment (up to 5 days).
The usual therapeutic dose of metoclopramide is 10 mg up to 3 times a day. The maximum daily dose is 30 mg or 0.5 mg/kg body weight. The maximum duration of metoclopramide treatment is 5 days.