Topical antifungal agents. Imidazole and triazole derivatives
The active substance of the medicine, miconazole, is an antifungal agent of the imidazole derivative group. Miconazole nitrate inhibits ergosterol biosynthesis and alters the lipid composition of the membrane, leading to the fungal cell death.
– Skin and nail fungal infections caused by dermatophytes or fungi of the Candida genus sensitive to miconazole.
– Superinfections caused by gram-positive bacteria.
The medicine is intended for topical use.
Fungal skin infections: Apply the medicine to the affected skin 2 times a day (morning and evening) and rub until full absorption, covering a small area around the lesion. Moist areas, skin folds (interdigital spaces, inguinal folds) should be washed and dried with a gauze cloth before medicine application.
The treatment course depends on the effectiveness of the treatment and the mycological test results, and ranges from 1 to 6 weeks. The average duration in skin candidiasis is 1–3 weeks, dermatophyte-caused infections - 3–4 weeks, and prolonged infections — 5–6 weeks.
The medicine use should be continued for at least 1 week after the clinical symptoms have disappeared.
Fungal nail infections: after preliminary filing down of the affected nail plate, apply the medicine as a thin layer to the nail bed 1–2 times a day, with subsequent occlusive dressing. Treatment should be continued for at least 3 months until a new nail is completely formed.
Depending on disease type and severity, the doctor may prescribe an individual dosing regimen and method of administration of the medicine.
The medicine is authorised for use in paediatric practice only after consultation with a physician.