Peripherial vasodilators. Nicotinic acid and its derivatives
Nicotinic acid (vitamin PP) by itself or in amide form is a prosthetic group of enzymes: codehydrase I (diphosphopyridine nucleotide– NAD) and codehydrase II (triphosphopyridine nucleotide - NADP), which are responsible for the transfer of hydrogen in redox reactions, as well as the transfer of phosphate. By participating in metabolism, tissue respiration, synthesis processes, nicotinic acid normalises the content of lipoproteins and triglycerides in the blood.
Treatment of pellagra (vitamin PP deficiency).
Ischemic cerebrovascular disorders. vasospasm in the limbs (obliterating endarteritis, Raynaud's disease). Renal vasospasm.
Wounds, ulcers that do not heal for a long time. Diabetic complications (diabetic polyneuropathy, microangiopathy).
Hypoacid gastritis, enterocolitis, colitis. Liver disease (acute and chronic hepatitis).
Facial nerve neuritis.
Intoxication of various genesis: professional, alcoholic, pharmaceutical (with aniline derivatives, barbiturates, anti-tuberculosis drugs, sulfonylamides).
Prescribe in adults and children from 15 years of age intravenously (slowly), intramuscularly and subcutaneously (intramuscular and subcutaneous injections are painful).
For intravenous push, dilute a single dose of the drug with 10 ml 0.9% sodium chloride solution; administer for at least 5 minutes (not more than 2 mg of nicotinic acid per 1 minute).
For intravenous drip, dilute a single dose of the drug in 100-200 ml of 0.9% sodium chloride solution, the rate of infusion — 30–40 drops per minute.
Prescribe in children of 15 years of age and over.