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Local anaesthetics

Local anaesthetic with moderate activity and a broad range of therapeutic effects. The anaesthetic mechanism is associated with blocking sodium channels, inhibition of potassium ion movement, competition with calcium, reduction of membrane phospholipid layer surface tension, inhibition of redox processes and impulse generation.

Local and infiltration anaesthesia, medical blocks.

In local anaesthesia, the dose depends on the concentration, nature of the surgery, method of administration, patient condition and age. For paranephric block in adults administer 50–70 ml of 0.5% (5 mg/ml) novocaine solution into paranephric body. The following highest doses (for adults) are established for infiltration anaesthesia: the first single dose at the beginning of surgery is not more than 0.75 g (i.e. 150 ml of 0.5% novocaine solution). Then no more than 2 g for each hour of operation (i.e. 400 ml of 0.5% novocaine solution).


Contraindicated in children.

Specialized edition for medical institutions and doctors.