Systemic antibacterial agents. Imidazole derivatives. Ornidazole
The ornidazole action mechanism is associated with damaging DNA structure in susceptible microorganisms. Ornidazole is effective against Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia (Giardia intestinalis), and some anaerobic bacteria such as Bacteroides, Fusobacterium spp.; anaerobic bacteria: Clostridium spp., susceptible strains of Eubacterium spp.; anaerobic cocci: Peptococcus spp., Peptostreptococcus spp.
Parenteral administration of the medicine is indicated in acute and severe infection or when oral administration is impossible, for the following diseases and conditions:
– anaerobic systemic infections caused by ornidazole-sensitive microflora: septicaemia, meningitis, peritonitis, postoperative wound infections, postpartum sepsis, septic abortion, and endometritis;
– prevention of infections caused by anaerobic bacteria in surgical interventions (especially in surgery on the colon and rectum), in gynaecological surgery;
– severe amoebic dysentery, all extra-intestinal forms of amoebiasis, giardiasis, liver abscess.
The dosage and duration of treatment are determined by the physician depending on the nature of the disease and the treatment regimen.
The medicine should be administered intravenously for 15–30 minutes.
For administration in children of more than 6 kg body weight.