Monocomponent angiotensin-converting enzyme (ACE) inhibitors. Perindopril
Perindopril is an inhibitor of the enzyme that converts angiotesin I in angiotesin II (angiotensin-converting enzyme — ACE). The converting enzyme, or kinase, is an exopeptidase that enables conversion of angiotesin I into vasoconstrictor angiotesin II, and causes the breakdown of vasodilator bradykinin into an inactive heptapeptide.
– heart failure;
– prevention of stroke recurrence in patients with cerebrovascular diseases;
– prevention of cardiovascular complications in patients with documented stable ischemic heart disease.
Prolonged treatment decreases the risk of myocardial infarction and heart failure (according to the results of the EUROPA study).
For oral administration.
4 mg and 8 mg Perindopres® tablets can be split in half to achieve a dose of 2 mg and 4 mg.
It is recommended to take tablets once per day in the morning before meals.
The dose should be selected on an individual basis depending on the blood pressure.