Systemic antibacterial agents. Other beta-lactam antibiotics. Second-generation cephalosporins. Cefuroxime
Second-generation cephalosporin antibiotic for parenteral administration. It has a bactericidal effect, disrupts the synthesis of the bacterial cell wall.
Treatment of infections caused by microorganisms susceptible to cefuroxime, or treatment of infections prior to the pathogen identification.
Infectious respiratory diseases: acute and chronic bronchitis, infected bronchiectasis, bacterial pneumonia, lung abscess, postoperative thoracic infections;
infectious nose and throat diseases: sinusitis, tonsillitis, pharyngitis;
infectious urinary tract diseases: acute and chronic pyelonephritis, cystitis, asymptomatic bacteriuria;
infectious soft tissue diseases:cellulitis, erysipeloid, wound infections;
infectious bone and and joint diseases: osteomyelitis, septic arthritis;
infections in obstetrics and gynaecology: infectious diseases of the pelvic organs;
gonorrhea, especially when penicillin is contraindicated;
other infectious diseases including septicaemias and meningites.
Prevention of infectious complications after thoracic, abdominal and pelvic surgery, in vascular, cardiovascular and orthopaedic surgeries.
Monotherapy with cefuroxime is effective in most cases, but if necessary, the drug can be used in combination with aminoglycoside antibiotics or with metronidazole (orally, in suppositories or injectable).
In case of a present or suspected mixed aerobic and anaerobic infection (e.g. peritonitis, aspirational pneumonia, abscess of the lungs, pelvic organs and brain) and a high probability of such infection (e.g. in operations on the large intestine and in gynaecological surgery), the use of cefuroxime in combination with metronidazole is acceptable.
In the treatment of pneumonia and exacerbation of chronic bronchitis, the drug can be prescribed before oral administration of cefuroxime axetil, if needed.
The susceptibility to cefuroxime varies in different regions and may change over time. If necessary, local antibiotic sensitivity data should be used for reference.
Before using the drug, a skin test for increased sensitivity to antibiotics is required.
The drug should be administered only intramuscularly and intravenously.