Angioselective calcium channel blocker
AmLodipine is a slow calcium channel blocker that blocks calcium ion entry through the membranes into the myocardial and vascular smooth muscle cells. The hypotensive action of amLodipine is related to its direct relaxing effect on the vascular smooth muscle.
– Arterial hypertension.
– Chronic stable angina.
– Vasospastic angina (Prinzmetal's angina).
Adults. For treating arterial hypertension and angina, the recommended initial dose is usually 5 mg of amLodipine once daily. Depending on the patient's response to the treatment, the dose can be increased up to the maximum—that is, 10 mg once daily.
Children over 6 years old with arterial hypertension. The recommended initial dose in this group of patients is 2.5 mg of amLodipine once daily. AmLodipine-Darnitsa 5 mg tablets are not intended to be divided into two to obtain a 2.5 mg dose; therefore, it is necessary to use the appropriate dosage form of amLodipine.
If the required blood pressure level is not achieved over 4 weeks, the dose can be increased up to 5 mg daily. The administration of doses of over 5 mg in this group of patients has not been studied.