Angiotensin-converting enzyme inhibitors
Enalapril maleate is a salt of maleic acid and enalapril, a derivate of two amino acids: L-alanine and L-proline. Angiotensin-converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to vasopressor angiotensin II.
– Treatment of hypertension.
– Treatment of clinically significant heart failure.
– Prevention of clinically significant heart failure in patients with asymptomatic left ventricular dysfunction (ejection fraction ≤ 35 %).
The tablets should be taken whole with a small amount of water regardless of food intake. Enalapril-Darnitsa should be taken at the same time every day and the prescribed dose should not be exceeded.
10 mg tablet can be divided; if the dose of 5 mg is prescribed, ½ tablet should be used.
In patients with a highly activated renin-angiotensin-aldosterone system (e.g. with renovascular hypertension, impaired salt and/or fluid balance, decompensated heart failure or severe hypertension) an excessive drop in blood pressure is possible after the initial dose is administered. An initial dose of 5 mg or lower is recommended for such patients, and the treatment should be initiated under the supervision of a physician.