Systemic antifungal agents. Triazole derivatives
Fluconazole, an antifungal agent of the triazole class, is a potent and selective inhibitor of fungal enzymes needed for ergosterol synthesis. The primary mechanism of its action is the inhibition of fungal lanosterol 14α-demethylation mediated by cytochrome P450, which is an integral stage of fungal ergosterol biosynthesis.
Acute vaginal candidiasis, candidal balanitis (when topical therapy is not appropriate).
The medicine should be used orally at a dose of 150 mg once. Capsules should be swallowed whole regardless of food intake.
If there are no signs of impaired renal function, the medicine should be used in the usual adult dose for this category of patients.
Patients with impaired renal function.
With a single use of fluconazole by patients with mild to moderate renal failure, a dose adjustment is not needed.
Patients with impaired hepatic function.
The medicine should be used with caution as there is insufficient information on the use of fluconazole in this category of patients.