Systemic antimicrobial agents. Aminoglycosides. Gentamicin
Gentamicin belongs to aminoglycosides with a broad action spectrum. Its mechanism of action is related to inhibition of the ribosomal 30S-subunit.
Considering the limited margin of safety of Gentamicin-Darnitsa, it should be used when the microorganisms are resistant to safer antibiotics.
Bacterial infections caused by gentamicin-sensitive microflora, in particular, lower respiratory infections, complicated urogenital infections, bone and joint infections, in particular, osteomyelitis, skin and soft tissue infections, infected burns, abdominal infections (peritonitis), central nervous system infections, in particular, meningitis in combination with β-lactam antibiotics, septicemia.
Gentamicin is intended for intramuscular or intravenous use. The dose, method of administration, and interval between the doses depend on the severity of the patient's condition. The dose regimen is calculated from the patient's body weight.
Intended for adults and children aged over 14 years.
The usual daily dose of gentamycin for patients with moderate to severe infections is 3 mg/kg body weight intramuscularly, divided into 2–3 single doses. The maximum adult daily dose is 5 mg/kg body weight, divided into 3–4 single doses. The usual duration of treatment for all patients is 7–10 days.
In severe and complicated infections, the course of treatment can be extended, if necessary. In such cases, it is recommended to monitor the renal function, hearing and vestibular apparatus, as the drug toxicity manifests after its administration for longer than 10 days.