Acidum aminocapronicum solution has hemostatic, antifibrinolytic effects in hemorrhages caused by increased fibrinolysis. Its action is related to blocking plasminogen activators and partial inhibition of plasmin effects.
Surgeries and pathological processes combined with increased fibrinolytic activity in the blood and tissues. To prevent secondary hypofibrinogenemia during massive transfusions of preserved blood.
The drug is used intravenously.
When a quick effect is needed (acute hypofibrinogenemia), adults should be administered no more than 100 ml 5% solution at 50–60 drops per minute for 15–30 min. 4–5 g should be infused during the first hour; in massive hemorrhage: 1 g hourly until complete bleeding arrest, but no more than 8 g. In recurrent bleeding, the drug should be infused at 4-hour intervals for no longer than 8 hours.
In moderately increased fibrinolytic activity, Acidum aminocapronicum-Darnitsa is administered at 0.05 g/kg body weight daily. The dose depends on the age: children aged under 1 year: once: up to 2.5 ml, daily: 15 mL; from 2 to 6 years: once: 2.5–5 ml, daily: 15–30 mL; from 7 to 10 years: once: 5–7 ml, daily: 30–45 ml, from 11 to 18 years: once: 7–14 ml, daily: 45–90 ml.
In acute bleeding, the doses are: children aged under 1 year: once: 5 ml, daily: 30 ml; 2 to 4 years: once: 5–7.5 ml, daily: 30–45 ml; 5 to 8 years: once: 7.5–10 ml, daily: 45–60 ml; 9 to 10 years: once: 15 ml, daily: 90 ml; 11 to 14 years: once: 20 ml, daily: 120 ml; 15 to 18 years: once: 28 ml, daily: 160 ml.
The course of treatment is 3 to 14 days.