Nimesulide is a nonsteroidal anti-inflammatory drug of the methanesulfonanilide group that has anti-inflammatory, analgesic and antipyretic properties. Nimedar's therapeutic effect is based on its interaction with the arachidonic acid cascade and reducing prostaglandin biosynthesis by cyclooxygenase inhibition.
Acute pain, primary dysmenorrhea.
Nimesulide should only be used as a second-line medicine. The decision to prescribe nimesulide should be made on the basis of an assessment of all patient-specific risks.
The medicine should be prescribed after a careful evaluation of the risk-benefit ratio. Use the lowest effective dose for the shortest possible time. The maximum duration of Nimesulide treatment course is 15 days.
Adults and children 12 years of age and over: take 1 tablet (100 mg) twice per day (daily dose of 200 mg).
Elderly patients: No dose adjustment is required.
Patients with impaired renal function: For patients with mild or moderate renal impairment (creatinine clearance of 30–80 ml/min), no dose adjustment is required The medicine should be taken borally after meals with a sufficient amount of liquid. In severe renal impairment (creatinine clearance <30 ml/h) the medicine is contraindicated.
Patients with impaired liver function. The use of nimesulide for the treatment of patients with impaired liver function is contraindicated (see the Contraindications Section).