Antibacterial agents of the quinolone group. Fluoroquinolones. Ofloxacin
The active substance of the medicine is ofloxacin, a synthetic broad-spectrum fluoroquinolone antibiotic. The bactericidal action mechanism of ofloxacin is associated with the inhibition of DNA gyrase, which arrests bacterial DNA replication.
Infectious diseases caused by pathogens, susceptible to ofloxacin:
– exacerbation of chronic obstructive pulmonary disease (including chronic bronchitis)*, community-acquired pneumonia*;
– uncomplicated acute cystitis*, urethritis*, acute pyelonephritis, and complicated urinary tract infections;
– complicated skin and soft tissue infections*;
– gonococcal urethritis and cervicitis caused by susceptible Neisseria* strains.
The official guidelines for the proper use of antibacterial agents should be followed.
*If it is impossible to use other antibacterial agents commonly used to treat this infection.
The medicine should be administered orally. Swallow the tablets with liquid. The interval between the administration of ofloxacin and the administration of sucralfate, zinc or iron supplements, aluminium/magnesium antacids should be at least 2 hours, as absorption of ofloxacin may be reduced when co-administered with these medicines.
The dose depends on the type and severity of the infectious disease. The adult dose range is 200 mg to 800 mg per day. Doses of up to 400 mg can be taken at once, preferably in the morning, and larger doses should be divided into two equal doses and taken at regular intervals.
Exacerbation of chronic obstructive pulmonary disease (including chronic bronchitis), community-acquired pneumonia: the medicine should be administered at a dose of 400 mg once per day, if necessary up to 400 mg twice per day.
Complicated skin and soft tissue infections: the medicine should be administered at 400 mg twice per day.
The medicine is contraindicated in children.