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Panthestin-Darnitsa®

Preventive and hygienic product

Preventive and hygienic product Panthestin-Darnitsa® - solution for external use based on dexpanthenol and miramistin. The product disinfects and promotes healing of wounds, scratches, and cuts. Dexpanthenol is rapidly converted in cells to pantothenic acid, which is one of the most important coenzymes of coenzyme A and has a significant effect on cell metabolism. Pantothenic acid is important for building the epithelium of the skin and mucous membranes. It promotes increased levels of mitosis and increases the strength of collagen fibres in wound healing. Miramistin has a pronounced bactericidal effect on gram-positive and gram-negative, aerobic and anaerobic bacteria in the form of monocultures and microbial associations, including hospital strains resistant to antibiotics, as well as herpes viruses, human immunodeficiency, etc. It has an antifungal effect on ascomycetes of the genus Aspergillus and genus Penicillium, yeast fungi and yeast-like fungi, dermatophytes, fungal microflora. It effectively prevents infection of wounds and burns, activates regeneration processes. It stimulates protective reactions at the site of application, through the activation of the absorption and digestive function of phagocytes, potentiates the activity of the monocyte-macrophage system. It has a pronounced hyperosmolar activity resulting in stopping wound and perifocal inflammation, absorbs purulent exudate, promoting the formation of dry scabs. It does not damage granulations and viable skin cells, does not inhibit marginal epithelialization. It does not have a local irritant effect.

Superficial skin lesions of any origin with a risk of infection: scratches, abrasions, cuts, cracks in the skin, burns, dermatitis. Diaper rash and dermatitis, prevention of their infection. Chronic skin lesions such as trophic leg ulcers and bedsores. Skin infections, such as secondarily infected eczema and secondarily infected neurodermatitis. Healing cracked nipples in breastfeeding women. Minimally invasive surgery: injuries and surgical wounds.

Apply to previously cleansed wounds or inflamed skin from one to several times a day. If necessary, a sterile gauze bandage can be applied. In the presence of exudate, the wound should be washed with furacilin solution (1: 5 000) or hydrogen peroxide (3%) and dried with a gauze napkin before application. The product can be used in paediatric practice (with the appearance of clinical signs of skin damage – from the first days of life). For children under 1 year of age, the product should be used at each diaper change until the disappearance of clinical signs of skin damage. The product can be used for children of different ages, including infants.

Preventive and hygienic product Panthestin-Darnitsa®,

skin spray, solution

Composition: Each ml solution contains: active ingredients: 50 mg dexpanthenol, 5 mg miramistin; excipients: D,L-pantolactone, purified water.

Pharmaceutical form. Skin spray, solution.

Properties. Solution for external use based on dexpanthenol and miramistin. The product disinfects and promotes healing of wounds, scratches, and cuts. Dexpanthenol is rapidly converted in cells to pantothenic acid, which is one of the most important coenzymes of coenzyme A and has a significant effect on cell metabolism. Pantothenic acid is important for building the epithelium of the skin and mucous membranes. It promotes increased levels of mitosis and increases the strength of collagen fibres in wound healing. Miramistin has a pronounced bactericidal effect on gram-positive and gram-negative, aerobic and anaerobic bacteria in the form of monocultures and microbial associations, including hospital strains resistant to antibiotics, as well as herpes viruses, human immunodeficiency, etc. It has an antifungal effect on ascomycetes of the genus Aspergillus and genus Penicillium, yeast fungi and yeast-like fungi, dermatophytes, fungal microflora. It effectively prevents infection of wounds and burns, activates regeneration processes. It stimulates protective reactions at the site of application, through the activation of the absorption and digestive function of phagocytes, potentiates the activity of the monocyte-macrophage system. It has a pronounced hyperosmolar activity resulting in stopping wound and perifocal inflammation, absorbs purulent exudate, promoting the formation of dry scabs. It does not damage granulations and viable skin cells, does not inhibit marginal epithelialization. It does not have a local irritant effect.

Indications. Superficial skin lesions of any origin with a risk of infection: scratches, abrasions, cuts, cracks in the skin, burns, dermatitis. Diaper rash and dermatitis, prevention of their infection. Chronic skin lesions such as trophic leg ulcers and bedsores. Skin infections, such as secondarily infected eczema and secondarily infected neurodermatitis. Healing cracked nipples in breastfeeding women. Minimally invasive surgery: injuries and surgical wounds.

Contraindications. Hypersensitivity to the ingredients of the medicinal product.

Warnings. Eye contact should be avoided. In case of contact with eyes, rinse immediately with plenty of water. Due to the presence of dexpanthenol, the product is not recommended for use in patients with haemophilia due to high risk of bleeding. As the product is almost not resorbed, it may be used during pregnancy or breastfeeding, but should be avoided on large areas of skin. If the product is used to treat cracked nipples, it should be washed off before breastfeeding. Not recommended for use with other antiseptics. Concomitant use with soap solutions should be avoided.

In case of individual intolerance, allergic reactions are possible, which are usually manifested by changes in the skin. This is accompanied by itching, redness, swelling, local or generalized rash, varying in clinical manifestations and severity. In some cases, local skin irritation is possible, accompanied by a burning sensation, which disappears by itself in 15–20 seconds and does not require discontinuation of the product.

If any side effects occur, discontinue use and consult a physician.

Method of administration. Apply to previously cleansed wounds or inflamed skin from one to several times a day. If necessary, a sterile gauze bandage can be applied. In the presence of exudate, the wound should be washed with furacilin solution (1: 5 000) or hydrogen peroxide (3%) and dried with a gauze napkin before application. The product can be used in paediatric practice (with the appearance of clinical signs of skin damage – from the first days of life). For children under 1 year of age, the product should be used at each diaper change until the disappearance of clinical signs of skin damage. The product can be used for children of different ages, including infants.

Shelf life. 2 years.

Shelf life. Store in the original package below 25 °C. Do not freeze. Keep out of reach of children.

Packaging. 30 ml in a vial, 1 vial with a spray tube in a pack.

Manufacturer. PRJSC Pharmaceutical company Darnitsa, 13, Boryspilska Street, 02093, City of Kyiv, Ukraine.

TU U 20.4-00481212-002:2021.

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