Predisolone has an anti-inflammatory, anti-allergic, immunosuppressive, anti-shock and anti-toxic action. In relatively large doses, it inhibits the activity of fibroblasts, synthesis of collagen, reticuloendothelial and connective tissue (retards the proliferative phase of inflammation), delays synthesis and accelerates catabolism of proteins in the muscle tissue, but increase their synthesis in the liver.
Intramuscular, intravenous administration:
systemic connective tissue diseases: systemic lupus erythaematosus, dermatomyositis, scleroderma, polyarteritis nodosa, ankylosing spondylitis;
haematological diseases: acute haemolytic anaemia, lymphogranulomatosis, granulocytopenia, thrombocytopenic purpura, agranulocytosis, different forms of leukemia;
skin diseases: common eczema, erythema multiforme, pemphigus vulgaris, erythroderma, exfoliative dermatitis, seborrheic dermatitis, psoriasis, alopecia, adrenogenital syndrome;
replacement therapy: Addisonian crisis;
emergency conditions: severe forms of nonspecific ulcerative colitis and Crohn's disease, shock (burn, traumatic, surgical, anaphylactic, toxic, blood transfusion shock), acute severe asthma, acute adrenal insufficiency, hepatic coma, severe allergic and anaphylactic reactions, hypoglycema.
Intraarticular administration: chronic polyarthritis, osteoarthritis of large joints, rheumatoid arthritis, post-traumatic arthritis, arthrosis.
Mixing and simultaneous use of prednisolone with other medicines in the same infusion system or syringe are not allowed!
The drug is intended for intramuscular, intravenous or intraarticular administration. The prednisolone dose depends on the disease severity.