Angiotensin II antagonists and diuretics. Valsartan and diuretics
The active hormone of the renin-angiotensin-aldosterone system (RAAS) is angiotensin II, converted from angiotensin I by the angiotensin-converting enzyme. Angiotensin II binds to specific receptors located on cell membranes in different tissues. It has a broad range of physiological effects, including both direct and indirect participation in blood pressure regulation.
Essential hypertension in patients whose blood pressure is not regulated properly with monotherapy.
The recommended dose of Tiara Duo is 1 80 mg/12.5 mg tablet per day. If the blood pressure is insufficiently reduced after 3–4 weeks of therapy, treatment with 1 160 mg/12.5 mg tablet per day should be considered. The 160 mg/25 mg tablets should be prescribed to patients who do not achieve sufficient blood pressure reduction when using 160 mg/12.5 mg tablets.