Systemic antimicrobial agents
Azithromycin belongs to the family of medications known as macrolide antibiotics - azalides, which have a broad spectrum of antimicrobial activity. The mechanism of action of azithromycin is related to interfering with bacterial protein synthesis via binding to the 50S-subunit of their ribosomes and preventing protein translation without any effect on the synthesis of polynucleotides.
Infections caused by microorganisms that are susceptible to azithromycin:
ENT infections (bacterial pharyngitis/tonsillitis, sinusitis, otitis media)
Respiratory tract infections (bacterial bronchitis, community-acquired pneumonia)
Skin and soft tissue infections: migratory erythema (early stage of Lyme disease), erysipelas, impetigo, secondary pyodermatoses
Sexually transmitted diseases: uncomplicated genital infections caused by Chlamydia trachomatis
Azicin should only be used in adults and children with a body weight of over 45 kg.
Azithromycin should be taken orally once daily not less than 1 hour before or 2 hours after a meal.
In infections of the upper and lower respiratory tract, skin and soft tissues (not including chronic migratory erythema): 500 mg (2 capsules) once daily for 3 days.
In chronic migratory erythema: on day 1: 1 g (4 capsules once), from day 2 to 5: 500 mg (2 capsules) daily.
In sexually transmitted infections: 1 g (4 capsules) once. The course dose is 1 g.
If a dose is missed, it should be taken as soon as possible, the next dose should be taken with a 24-hour interval.
In case of renal failure with insignificant kidney dysfunction (creatinine clearance > 40 mL/min), dose adjustment is not needed. Azithromycin should be administered with caution in patients with severe renal failure (glomerular filtration rate < 10 mL/min).
In case of liver failure, the drug should not be used in patients with severe liver disease, as azithromycin is metabolized in the liver and excreted in the bile.
In elderly patients, no dose adjustment is needed.
Azicin in this dosage form can be used in children with a body weight of over 45 kg.
In children with a body weight of under 45 kg, other dosage forms of azithromycin should be used.